|Date:||November 12, 2015 | 9:00 am – 5:00 pm
November 13, 2015 | 9:00 am – 2:00 pm
|Location:||University of Texas at San Antonio
HEB University Center (HUC) Ballrooms
One UTSA Circle
San Antonio, TX 78249
The broad focus of the Alt lab is the elucidation of mechanisms that generate antigen receptor diversity in the Immune system and mechanisms that maintain genomic stability in mammalian cells. The lab studies V(D)J recombination in developing B and T lymphocytes and IgH heavy chain class switch recombination (CSR) and somatic hypermutation in mature B lymphocytes. Studies of these processes continue to employ biochemical, molecular and mouse modeling approaches to elucidate mechanisms by which the RAG endonuclease and Activation Induced Cytidine Deaminase function on DNA to initiate, respectively, VDJ recombination and CSR.
Ongoing work seeks to elucidate mechanistic elements (three dimensional genome organization, DSBs, transcription, epigenetic modifications, repair pathways, etc) that contribute to the formation of translocations and other forms of genomic instability in mouse and human cancer cells.
Dr. Alt received his Ph.D. in Biological Sciences from Stanford University.
Research in Dr. Finlay’s lab is directed at studying the interactions that occur between pathogenic bacteria and host cells, including the molecular mechanisms of host-parasite interactions of intracellular bacteria. Several adherent and invasive bacterial pathogens are used for comparative purposes, including salmonella species and pathogenic Escherichia coli strains. The lab has developed several model systems to study such processes, including polarized epithelial cell layers, an in vitro blood brain barrier, and other cultured cell systems. Current work is based on identifying bacterial and host products necessary for adherence, invasion, intracellular survival, and intracellular replication. The lab is also examining signals that are transduced in the host cell by enteropathogenic Eschericia coli (EPEC), and determining how this relates to host cell cytoskeletal rearrangements and bacterial attachment.
Dr. Finlay received his Ph.D. from the University of Alberta.
Dr. Iverson’s research involves the production, characterization, and manipulation of large, functional molecules from three different points of view.
1) Antibody and enzyme engineering with an emphasis on developing better methods for recombinant antibody or enzyme cloning and directed evolution. The lab has recently extended the work to include manipulation of enzyme catalysts.
2) Artificial macromolecules with defined higher order structure and function. These systems involve the predictable folding of synthetic molecules into stable scaffolds, based on abiotic secondary structure elements.
3) The chemistry of nucleic acid binding, recognition and modification with a primary focus on understanding and exploiting newly created polyintercalating molecules. The lab has recently used high filed NMR to determine the structure of the first threading tetraintercalator bound to its preferred site in double stranded DNA.
Dr. Iverson received his Ph.D. from the California Institute of Technology.
Dr. O’Riordan’s lab explores the interaction of intracellular bacterial pathogens with their host cells. They primarily study the Gram-positive bacterium Listeria monocytogenes, a facultative intracytosolic pathogen, investigating mechanisms of adaptation to the host cell environment. In addition, the lab uses L. monocytogenes and other bacterial pathogens as tools with which to explore host mechanisms that regulate infection and innate immune signaling. Projects in the lab focus on defining host:pathogen interactions that regulate infection by the intracellular bacterial pathogen L. monocytogenes: 1) elucidating pathways of bacterial metabolism that govern life of L. monocytogenes inside a host organism; and 2) determining key regulatory mechanisms by which the mammalian host initiates protective immunity in response to bacterial pathogens.
Dr. O’Riordan received her Ph.D. in Immunology from the University of California, San Francisco.